J. Seo

The refinement of repeated exact time-to-event modeling: methodological refinements and implementation in NONMEM® —part I

Background Parametric time-to-event (TTE) modeling is widely used in clinical trials to evaluate treatment response, patient prognosis, and drug-related adverse events (AEs). As follow-up assessments increasingly capture recurrent AEs, there is a growing need for analytical approaches that extend beyond traditional sin...