In this study, we present the largest rare coding variant association study of schizophrenia to date, with 87,959 schizophrenia cases and 150,587 controls. We identify 16 genes at exome-wide significance: SETD1A, ZMYM2, HERC1, RB1CC1, SCAF1, XPO7, SP4, FYN, PPP3CA, CUL1, HDAC9, JARID2, ATP9A, PTK2, STAG1, and SCN2A, an...
J. Sealock, C. Dowd, Calwing Liao et al.· bioRxiv· 1 citation
Together, these results implicate a constellation of rare variants that map onto neuronal biology and demonstrate that diverse global populations converge on shared genetic signals underlying BD risk.
Calwing Liao, Robert Ye, J. Sealock et al.· medRxiv· 0 citations
Genetic studies of serious mental illness (SMI, including schizophrenia and bipolar disorder) have implicated two classes of risk variant: common variants1-3, each of small effect but collectively accounting for most population-level risk, and ultra-rare coding variants4,5 which confer large risk in a small number of i...
Greta Gerdes, V. Tozzo, S. Service et al.· medRxiv· 0 citations
A genomic meta-analysis of case–control studies of binge-eating behavior and analyses of anorexia nervosa and its subtypes, alongside analyses of AN, identified six BE-associated loci and eight areas that are associated with anorexia nervosa, in people of European ancestry.
Jet D. Termorshuizen, Helena L. Davies, Sang-Hyuck Lee et al.· Nature Mental Health· 1 citation
This study finds that rare variants across hundreds of genes contribute to autism with variable phenotypic outcomes, and clusters them based on association evidence from large-scale studies of developmental disorders, schizophrenia, bipolar disorder, and epilepsy.
F. Satterstrom, C. Auwerx, J.-M. Fu et al.· medRxiv· 1 citation
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