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J. Schonhoft

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Open access Sep 2026

Targeting Polθ Helicase with RP-3467: Preclinical Validation and Clinical Response in a gBRCA1 ovarian cancer patient with an acquired PARPi resistance mutation in TP53BP1

It is demonstrated that RP-3467 potently suppresses Pol{theta} enzymatic activity, abrogates MMEJ, and disrupts mitotic DNA repair in HR-deficient (HRD) models, inducing synthetic lethality.

E. Rosen, Marie-Claude Mathieu, Gino B. Ferraro et al. · medRxiv · 0 citations