Leishmaniasis remains a major neglected tropical disease in Eastern Africa, where transmission is driven by the ecological diversity and geographic distribution of phlebotomine sand flies. Despite their epidemiological importance, regional sand fly occurrence data remain fragmented across historical reports, institutio...
K. Agboka, Souleymane Diallo, K. Ahmed et al.· Acta Tropica· 0 citations
Leishmania parasites must rapidly adapt to fluctuating environments to ensure survival and transmission. While acidic pH in the sand fly vector is a conserved developmental trigger, sensing mechanisms remain poorly understood. Using a barcoded protein kinase library, we screened for regulators of acid adaptation in Lei...
L. V. de Liz, J. Sádlová, Barbora Bečvářová et al.· bioRxiv· 0 citations
This study investigated effectors in the canonical RNAi response and the Piwi protein of the human pathogen L. (Viannia) guyanensis by gene ablation and identified Dicer-like and Argonaute 1 proteins of the canonical RNAi pathway as critical for controlling viral RNA levels, suggesting that control of viral replication...
Donnamae Klocek, Rhys H. Parry, G. A. Kay et al.· bioRxiv· 0 citations
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