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Author

J. S

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Sep 2026

Yohimbine attenuates bleomycin-induced skin fibrosis by modulating the PI3K/Akt-MAPK signaling: an integrated network pharmacology and in vivo study

It is demonstrated that yohimbine attenuates skin fibrosis by suppressing inflammatory and fibrotic responses, potentially through modulation of PI3K/Akt-MAPK signaling, and may represent a potential lead for further investigation in fibrotic skin disorders.

Abhisheik Eedara, J. S, Yogesh Chandra et al. · 0 citations
Open access Aug 2026

Sinigrin Mitigates Pulmonary Inflammation and Fibrosis Partly through Adenosine Monophosphate-Activated Protein Kinase (AMPK) Signaling.

Gen and protein expression analyses demonstrated that SNG dose-dependently attenuated the bleomycin-induced inflammatory and fibrotic marker expression, and mechanistic investigations demonstrated that SNG exerts its anti-inflammatory and antifibrotic effects partly through activation of AMPK signaling.

Suriya Panneerselvam, J. S, Anoop Kishore et al. · 0 citations

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