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Author

J. Rydzewski

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2 papers indexed here

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Oct 2026

Decoding Conformational Dynamics and Hyperactivity of Histone H3K36 N -Methyltransferase in Oncogenic Mutations via tICA and Markov State Modeling

NSD2 is a histone methyltransferase that modifies lysine 36 in histone H3 (H3K36), playing a central role in chromatin organization and transcriptional regulation. Oncogenic mutations, such as E1099K and T1150A in NSD2, have been associated with hyperactive methylation, but the molecular mechanisms underlying this ga...

Tejas Shah, Sahar Heidari, J. Rydzewski et al. · 0 citations
Preprint Sep 2026

Computational Insights into Mechanostability and Dissociation Dynamics of the Dengue Virus Envelope Protein Ectodomain Dimer Across pH and Temperature Gradients

Dengue virus (DENV) is an enveloped flavivirus of major public health importance. Its envelope (E) protein mediates viral entry through homodimer dissociation and subsequent membrane fusion, making it one of the principal targets for antiviral strategies. To investigate the molecular determinants of this process, we pe...

G. Ropón-Palacios, Luís G. F. Crespi, J. Rydzewski et al. · 0 citations

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