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J. Ruud

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Open access Sep 2026

Semaglutide engages distinct brainstem-to-hypothalamus circuits to suppress motivated feeding and regulate ketogenesis and energy expenditure

stimulation of semaglutide-responsive NTS projections to both hypothalamic regions recapitulates key effects of the corresponding Adcyap1NTS pathways on palatable-food intake and metabolism, while also suppressing fasting-induced AgRP neuron activation, demonstrating that these pathway-specific functions are retained w...

Sebastian Blid Sköldheden, Júlia Teixidor-Deulofeu, J. Ruud et al. · 0 citations

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