Author

J. Rosenbluth

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Open access Oct 2026

Same-cell mapping of epigenetic regulatory state to functional proteomic output

To profile chromatin accessibility and cytoplasmic protein from the same cell, we introduce Proteo-Seq, a single-cell tool that physically routes each cell’s cytoplasmic proteome to either targeted or discovery proteomics and each cell’s intact nucleus to single-nucleus ATAC sequencing (snATAC-seq). The device comprise...

Xin Wang, Md Nazibul Islam, C. Deroy et al. · bioRxiv · 0 citations

Open access Aug 2026

BAF perturbation heightens cancer cell dependence on CDK12-driven transcription elongation by RNA polymerase II

CDK12 facilitates transcriptional elongation and processivity by RNA polymerase II (Pol II). Although it has emerged as a promising actor and target in cancer, better understanding of CDK12 gene transcription control could inform the design of novel anti-cancer strategies. Here, we identify a co-dependency between CDK1...

Monika Mačáková, Cassidy Danyko, Stefan Oberlin et al. · bioRxiv · 0 citations