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Inflammation in pregnancy and child neurodevelopment: A trio polygenic score and Mendelian randomization study in the Norwegian mother, father and child cohort.
BACKGROUND Inflammation in pregnancy induced by chronic disease, infection, or environmental exposures has been associated with neurodevelopmental conditions in observational study designs. OBJECTIVE To investigate causal effects of pregnancy inflammation on offspring neurodevelopment in the Norwegian Mother, Father...
Neurocognitive profiles in early childhood in relation to clinical and functional outcomes in middle childhood in offspring at familial high-risk of schizophrenia or bipolar disorder: The Danish High-Risk and Resilience Study.
BACKGROUND Widespread neurocognitive impairments exist in children at familial high-risk of schizophrenia (FHR-SZ), whereas evidence is mixed in children at FHR of bipolar disorder (FHR-BP). Neurocognitive heterogeneity is well-established, but associations with longitudinal clinical and functional outcomes remain unex...