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Author

Jian-Xun Qi

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Open access Sep 2026

Discovery of the nucleoside analogue FMAU as a broad-spectrum anti-orthopoxvirus inhibitor in vitro and in vivo using a structure-guided hit expansion strategy

In vivo mouse studies showed that FMAU treatment provided full protection against lethal VACV and MPXV challenges, while significantly reducing viral loads in lung tissues, and oral FMAU administration retained potent therapeutic efficacy against MPXV in a mouse model of MPXV infection.

Ting-Ting Zheng, Yong Feng, Chang Xu et al. · 0 citations
Open access Aug 2026

A structural and mechanistic atlas of NTD antibody neutralization and immune escape across SARS-CoV-2 prototype and its (sub-)variants.

Mechanistic studies reveal that NTD-5 and NTD-9 antibodies neutralize by inducing S1 shedding, thereby extending this mechanism to selected NTD-directed antibodies and providing a structural and mechanistic framework for rational vaccine and antibody design resilient to antigenic drift.

Jian-Jie Zhou, Wen-Yu Li, Xiaoyu Wang et al. · 0 citations

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