Metal-Polyphenol Network-Based Biomaterials for Infected Bone Defects: Microenvironment Regulation and Stage-Oriented Regenerative Strategies.
Infected bone defects are not simply bone defects complicated by bacterial infection; they are dynamic pathological niches in which biofilms, intracellular bacterial persistence, oxidative stress, dysregulated immunity, vascular failure, and pathological bone remodeling are mutually reinforcing. This coupling explains...