Aging is an inevitable biological process marked by progressive functional decline and elevated risk of cardiovascular diseases (CVDs). This review systematically examines the clinical mechanisms linking aging to cardiovascular pathology, focusing on molecular, cellular, and physiological changes that contribute to cardiovascular aging, which in turn increases the incidence of heart failure, atherosclerosis, atrial fibrillation, and other diseases. Key mechanisms include metabolic dysregulation, mitochondrial dysfunction, chronic inflammation, cellular senescence, immune disorders, and epigenetic changes. Understanding these mechanisms is crucial for developing targeted interventions to delay cardiovascular aging and alleviate CVD burden in older people. Current therapeutic strategies, including lifestyle modifications, pharmacotherapy, gerotherapeutic interventions, and device-based management, are reviewed, along with future directions in precision medicine, development of novel therapeutic targets, multi-omics, and AI-powered strategies against cardiovascular aging.
Obesity, given its strong association with cardiovascular diseases (CVDs), is a major global public health issue attracting increasing attention. This comprehensive review systematically synthesizes clinical and basic research progress in elucidating the complex relationship between obesity and CVDs. We explore the epidemiology, pathophysiology, clinical manifestations, and management strategies for obesity-related CVDs. Drawing on recent studies, we highlight the effects of obesity on atherosclerotic disease, cardiomyopathy, heart failure, arrhythmias, hypertension, and venous thromboembolism. Understanding these mechanisms is essential for developing effective prevention and treatment strategies to decrease the cardiovascular burden associated with obesity. Furthermore, this review summarizes current therapeutic approaches for obesity-related CVDs, such as lifestyle interventions, pharmacotherapy, and metabolic surgery, and discusses future research directions, including precision medicine, exploration of novel therapeutic targets, and single-cell spatiotemporal omics.
Naiqi Liu, Yi Pan, Fuk L Liu et al.· Cardiovascular Innovations a...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
