J. Piešťanský

Abstract collection from the 1st structural biology and biophysics symposium– SBF 2026

S1–P1 nucleases are medium-sized enzymes (25–40 kDa) that share a distinctive active site built around a cluster of three zinc ions. They function as phosphoesterases, cleaving the P–O3 ′ bond in nucleic acids and producing 5 ′ -mononucleotides. What makes this enzyme family particularly interesting is its broad substr...