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Author

J. P. Thiery

h-index 17 View on Semantic Scholar

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Aug 2026

FUS inactivation promotes leptomeningeal metastasis of lung cancer through the up-regulation of CD36.

The prognosis of non-small cell lung cancer (NSCLC) with leptomeningeal metastasis (LM) is dismal. The regulators of LM progression remain elusive, thus impeding effective clinical intervention. Here, we performed in vivo genome-wide CRISPR-based screens and found that fused in sarcoma (FUS) ablation promoted LM in bot...

Shou-Heng Lin, Kai Yin, M. Zheng et al. · 0 citations
Review Open access Aug 2026

Epithelial–mesenchymal transition in carcinoma: navigating phenotypic states to target resistance and metastasis

The clinical translation of EMT-directed interventions faces steep methodological hurdles, primarily driven by unverified causal dynamics and unresolved therapeutic safety profiles, and will require dynamic, multi-pronged strategies tailored to specific carcinoma cell states and spatial niches.

Xuecong Wang, C. Zhang, Yi Zhao et al. · 0 citations

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