Author

J. P. Gisbert

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Open access Sep 2026

Uncovering combination therapies for immune-mediated inflammatory diseases through systems biology analysis on longitudinal patient data.

While targeted therapies have reshaped the clinical management of immune-mediated inflammatory diseases (IMIDs), primary non-response remains a major obstacle for many patients. Combining two targeted therapies is an emerging strategy to overcome this therapeutic ceiling, but the number of possible drug pairs makes pri...

S. Martínez-Mateu, Y. Guillén, Edgar Angelats et al. · Cell Reports Medicine · 1 citation

Open access Sep 2026

Tofacitinib does not affect platelet function or coagulation in patients with ulcerative colitis

Tofacitinib treatment was not associated with increased platelet aggregation, platelet activation, or enhanced coagulation in patients with UC.

F. Suárez-Trujillo, P. J. Martínez, I. Soleto et al. · Frontiers in Immunology · 0 citations

Review Open access Sep 2026

Emerging CAR-Treg and regulatory T cell therapies for inflammatory bowel diseases: a systematic review of a new era of treatment

Background Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by dysregulated mucosal immunity. Despite major advances in therapies, a high proportion of patients do not achieve or sustain remission. Cellular immunotherapies have emerged as a mechanistically distinct therapeutic strate...

F. Suárez-Trujillo, Theodore S. Steiner, J. P. Gisbert et al. · Frontiers in Immunology · 0 citations