Author

J. Ohana

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Open access Oct 2026

Aging remodels the human muscle secretome, impairing stem cell via sphingolipid metabolism

Aging reduces skeletal muscle regenerative capacity, but how the aged environment impairs muscle stem cells (MuSCs) remains unclear. Skeletal muscle acts as a secretory organ, yet age-related changes in its secretome and impact on stem cells are poorly understood. We performed proteomic and lipidomic analyses of condit...

B. Crisol, Natalia Pinzón, M. Bensalah et al. · bioRxiv · 0 citations

Open access Aug 2026

Comprehensive transcriptomic profiling reveals impaired polyamine metabolism as a contributor to age-related muscle decline

A spatial transcriptomic atlas of skeletal muscle from young and aged mice is presented, resolving transcriptional reprogramming across fiber types and tissue compartments and revealing alterations in sarcomeric organization, excitation-contraction coupling, oxidative stress responses, and fiber type-specific metabolic...

Veronica Ruggieri, Andrea Bracaglia, Lorenza Esposito et al. · iScience · 0 citations