Author

J. Morgado-Díaz

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Review Open access Oct 2026

Cancer-associated fibroblasts as key mediators of therapeutic resistance and tumor progression in colorectal cancer

Cancer-associated fibroblasts (CAFs) are instrumental in tumor progression by interacting with tumor cells, other stromal components, and the extracellular matrix (ECM) within the tumor stroma. The origin, heterogeneity, and activation mechanisms of CAFs in different cancer types have been widely reported....

Bárbara Martins de Lima Coelho, L. B. Murad, Renata Machado Brandão Costa et al. · Cancer Cell International · 0 citations

Open access Sep 2026

Pharmacological inhibition of the canonical Wnt/β-catenin signaling pathway sensitizes 5-fluorouracil-resistant colorectal cancer cells

The study findings suggest the use of combinatorial therapies using conventional agents, such as 5-FU, and inhibitors of this pathway, as a useful therapeutic strategy to treat patients with colorectal cancer.

D. A. A. Ramos, Daniela Filomena Tavares de Pina, A. C. M. Sousa-Squiavinato et al. · Molecular Biology Reports · 0 citations