Author

J. Mandula

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Open access Aug 2026

IFN-γ-driven iNOS induction in macrophages mediates CAR T cell resistance in B cell lymphoma

Chimeric antigen receptor (CAR) T cell therapies have revolutionized B cell malignancy treatment, but many patients with large B cell lymphoma (LBCL) experience primary resistance or relapse. To uncover resistance mechanisms, here we examine pre-infusion tumor biopsies and observe that increased immunoregulatory macrop...

SaeBom Lee, A. Pavy, Nolan J. Beatty et al. · Nature Communications · 0 citations

Jul 2026

Developing Novel Bispecific T-cell Engager Therapy by Concurrent Targeting GARP on Cancer Cells and Regulatory T cells 2258672

It is demonstrated that elevated GARP expression in human tumors correlates with poor survival and higher relapse rates after first-line therapies after first-line therapies, and the Anti-GARP/CD3 platform holds the promise as a novel therapy of cancer immunotherapy worthy for clinical translation.

Ziyu Wang, Yaa S Amankwah, J. Mandula et al. · Journal of Immunology · 0 citations

Open access Aug 2026

Extracellular vesicle-mediated suppression of macrophage STING signaling promotes immune dysfunction in dedifferentiated liposarcoma

Background Dedifferentiated liposarcoma (DDLPS) is characterized by abundant immune cell infiltration yet derives limited benefit from immune checkpoint blockade and stimulator of interferon genes (STING) agonist-based strategies, suggesting tumor-mediated suppression of antitumor immunity. Tumor-associated macrophages...

Qi Zhang, J. Mandula, Patricia Sarchet et al. · bioRxiv · 0 citations