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J. Machado

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Open access Sep 2026

Combinatorial targeting of the miR-379/miR-410 cluster normalizes glucose and lipid homeostasis in male models of diabetes and obesity

Non-coding RNAs from the Dlk1-Dio3 locus are critical for the maturation of metabolic tissues in early stages of postnatal development; however, their role in the mature organs remains elusive. Herein, we show that microRNAs from the miR-379/miR-410 cluster are robustly upregulated in livers of subjects with obesity an...

Manuel Gil-Lozano, E. Simoes, Mo-Ya Wu et al. · 0 citations
Open access Sep 2026

Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia

Tumor-secreted ADAMTSL4 activates latent TGFβ1 at muscle cell surfaces, promoting muscle atrophy and fibrosis while also driving adipose tissue wasting, and represents a selective therapeutic target for cancer cachexia.

J. Machado, Vignesh Karthikaisamy, Hermine Mohr et al. · 1 citation
Open access 2026

Sustainable bioformulation of Trichoderma asperellum, Pseudomonas fluorescens, and Bacillus subtilis enhances agricultural productivity in different Brazilian states

ABSTRACT The use of plant growth-promoting microorganisms (PGPM) is a promising strategy to enhance crop productivity while improving soil functionality. This study evaluated the efficacy of fungal-bacterial consortium of Trichoderma asperellum, Pseudomonas fluorescens, and Bacillus subtilis, for promoting the growth o...

A.C.C. Bortolassi, A. D. de Almeida, E. Meyer et al. · 0 citations
Open access Jul 2026

Coinoculation of Pantoea phytobeneficialis PF55 and Trichoderma harzianum ESALQ 1306 enhances soil microbial activity and agronomic performance in onion

Coinoculation with growth-promoting microorganisms has proven to be an efficient strategy for enhancing the agronomic performance of onion (Allium cepa L.). This study evaluated the effect of inoculating Pantoea phytobeneficialis PF55 and Trichoderma harzianum ESALQ 1306, applied individually and in combination, on agr...

J. Machado, E. Meyer, Lázaro Nanque et al. · 0 citations

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