J. M. García-Heredia

Alternative Isoforms as Molecular Modulators of Cellular Senescence in Cancer

Cellular senescence is a stress-induced, stable proliferative arrest that acts as a potent barrier to tumorigenesis, yet the senescence-associated secretory phenotype that accompanies it can paradoxically fuel inflammation, angiogenesis and the phenotypic plasticity contributing to tumor heterogeneity, therapy resistan...