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Author

J. M. de Castro e Sousa

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Review Open access Oct 2026

Three-dimensional in vitro models for assessing temozolomide sensitivity in glioblastoma

IDH-wildtype glioblastoma, or glioblastoma multiforme (GBM), is the most aggressive primary malignancy of the central nervous system. It is characterized by marked invasiveness, intratumoral heterogeneity, and high recurrence rates, largely driven by intrinsic and acquired resistance to standard temozolomide (TMZ) th...

Andresa Hiromi Sakai, M. Sakalem, Luiza Caroline Oliveira Rocha et al. · 0 citations
Open access Aug 2026

A mechanistic approach about oxidative, mutagenic, and cytotoxic effects of an organotellurane.

RF07 exhibits antiproliferative action on animal cells, high toxicity on Artemia salina nauplii, as well as clastogenic effects on growing roots.

Felipe Emannuel Alvino de Jesus, Octávio Augusto de Carvalho Maia, Antonielly Campinho Dos Reis et al. · 0 citations

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