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Author

J. Low

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2 papers indexed here

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Open access Oct 2026

A genetically regulated SKAP2 switch modulates human T lymphocyte adhesion and migration

Spinella et al. linked a Crohn’s disease risk allele regulating SKAP2 expression to T lymphocyte function. SKAP2 enhances cell adhesion while suppressing migration. Sustained TCR signaling triggers its proteolytic cleavage to enable migration. Overall, genetic alteration of SKAP2 levels drives T cell dysfunction and pr...

Mara Cetty Spinella, Francesco Gualdrini, Cristina Leoni et al. · 0 citations
Open access Aug 2026

DUSP4 promotes anti-tumor CD8+ T cell function and boosts CAR-T cell efficacy in mouse colorectal cancer

The activation and function of CD8+ T cells, which are central for anti-tumor immunity, are tightly regulated by extracellular and intracellular signaling pathways. Dual-specificity phosphatases (DUSP), including DUSP4, dephosphorylate serine/threonine and tyrosine residues of proteins to modulate cellular signaling. H...

Heng Li, Clara K. T. Koh, Tian-Shuai Zhang et al. · 0 citations

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