Author

J. Loscalzo

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Open access Aug 2026

2-Hydroxyglutarate Redirects Fatty Acid Partitioning to Mitigate Lipotoxic Stress and Preserve Metabolic Fuel

The role of 2-hydroxyglutarate in lipid metabolism is currently unknown. Here we show that 2HG redistributes the partitioning of fatty acids into triglyceride storage and away from membrane phospholipid synthesis, mitochondrial oxidation, and lipotoxic intermediates. In primary human cardiac and vascular cells, both en...

N. Vigder, Amit Chandra, Nishith M. Shrimali et al. · bioRxiv · 0 citations

Review Open access Sep 2026

Artificial intelligence in clinical trials—state of the evidence, gaps, and next steps

Summary Artificial intelligence (AI) affects clinical trials in two distinct but overlapping ways: as the intervention under evaluation and as infrastructure supporting trial design, recruitment, monitoring, endpoint assessment, analysis, and reporting. In this manuscript, we define AI-as-intervention as AI whose outpu...

A. Armoundas, C. Tarabanis, J. Loscalzo · EClinicalMedicine · 0 citations