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Case report Open access Sep 2026

Tenofovir in Progressive Multifocal Leukoencephalopathy

Objectives Progressive multifocal leukoencephalopathy (PML) is a rare, often fatal demyelinating disease of the CNS caused by reactivation of the JC polyomavirus (JCV), typically in immunocompromised individuals. As no specific therapy against JCV exists, current management focuses on immune reconstitution. Recently, a...

J. Lier, A. Mrestani, Max Braune et al. · 0 citations
Sep 2026

Analysis of Interindividual Lesion Progression Variability in Adult Cerebral Adrenoleukodystrophy.

BACKGROUND AND OBJECTIVES Cerebral adrenoleukodystrophy (cALD), the most severe clinical phenotype of X-linked adrenoleukodystrophy (X-ALD), is characterized by rapidly progressive, inflammatory destruction of the cerebral white matter. In adult patients, therapeutic options are limited to hematopoietic stem cell trans...

M. Ponleitner, J. Lier, Luc Bracoud et al. · 0 citations

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