Author

J. Leskovec

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Open access Aug 2026

Hypothalamic Cell Type Evolution across Vertebrates

The hypothalamus regulates vital functions and is highly conserved among vertebrates occupying diverse niches, but little is known about the evolution of its cell types. Using comparative single-cell transcriptomics across major vertebrate classes, we identified deeply conserved and clade-specific cell types. While hom...

Yun-Ming Wu, Prateek Kalakuntla, Billie C. Goolsby et al. · bioRxiv · 0 citations

Open access Aug 2026

Predicting cellular responses to perturbation across diverse contexts with State.

The performance and flexibility of State set the stage for scaling the development of AI models of cell state, a machine learning model that predicts perturbation effects while accounting for cellular heterogeneity within and across experiments.

Abhinav K. Adduri, Dhruv Gautam, Beatrice Bevilacqua et al. · Cell · 4 citations

Open access Aug 2026

Perturb-ME: Scalable mechanism discovery from phenotype-enriched genome-wide screens

Perturb-ME, along with agentic interpretation, provide a scalable framework for comprehensive functional discovery from phenotype-enriched genetic screens and combines genome-scale CRISPR screening, phenotype-based enrichment and multimodal single-cell profiling.

Han-Chen Wang, Jiacheng Gu, Chris J. Frangieh et al. · bioRxiv · 0 citations