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The study shows that presence of depression in drug-resistant patients with mesial temporal lobe epilepsy is linked to hippocampal disfunction rather than neuronal density in the hippocampus.
Epilepsy surgery preserved intellectual functioning, particularly in FL and PC procedures, however, persistent VCI decline in H and TL groups suggests effects on verbal abilities associated with temporal lobe involvement, and group-level trajectories rather than individual outcomes.
Palliative surgical procedures for pediatric DRE are safe and associated with seizure reduction, decreased medication burden, and gradual improvement in adaptive functioning and early surgical intervention may help minimize developmental decline and improve long-term adaptive outcomes.
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