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Author

J. Lehtiö

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Open access Sep 2026

Therapy induced senescence promotes immunogenicity in acute myeloid Leukemia through reduced EZH2 activity

Chemotherapy resistance and disease relapse are major determinants of treatment failure in acute myeloid leukemia (AML). Therapy-induced senescence (TIS) is one outcome of chemotherapy, but its immunological consequences in AML remain unclear. Here we show that ex vivo chemotherapy induces senescence in a subset of the...

Diego Gilioli, Simona Fusco, Teresa Tavella et al. · 0 citations
Open access Aug 2026

A reference protein atlas of the adult mouse brain vasculature

This work used isolated brain vascular fragments to study the blood–brain barrier and applied a combination of deep bulk proteomic analysis, a proteomic ruler approach, and scRNA-seq, assuming a high within-gene correlation between mRNA and protein.

Li-Qun He, Henrik J. Johansson, E. Vázquez-Liébanas et al. · 0 citations
Open access Jul 2026

Assessing clinical decision support system tools in precision oncology: piloting ring testing

An international ring test documenting CDSS usage, performance, and manual interpretation revealed clinically relevant discrepancies between laboratories and interpreters, underscoring the need for structured external quality assessment schemes for CDSS tools in addition to the existing laboratory workflow schemes.

V. Nygaard, S. Zhao, D. Tamborero et al. · 0 citations

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