Author

J. Kött

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Open access Oct 2026

Poliosis predicts durable response to immune-checkpoint blockade in metastatic melanoma: a multicenter cohort study

Abstract Background Immune checkpoint blockade (ICB) improved survival outcomes for patients with metastatic melanoma. Yet up to 65% of patients experience primary resistance and nearly half of initial responders acquire resistance. The clinical utility of ICB is further tempered by frequent immune-related adverse even...

A. Brekner, M. Mengoni, J. Kött et al. · Journal for ImmunoTherapy of... · 0 citations

Open access Sep 2026

Incidence and Predictors of Immune-Related Hypothyroidism Under Pembrolizumab Across Gynecologic Malignancies and Melanoma: A Real-World Cohort Study.

Immune checkpoint inhibitors (ICIs) frequently cause thyroid immune-related adverse events (irAEs). Permanent hypothyroidism, the clinically most relevant phenotype, requires lifelong hormone replacement. We investigated its incidence, course, risk factors, and prognostic relevance under pembrolizumab. This retrospecti...

Freya Koffka, Johann Kornowski, E. Laakmann et al. · International Journal of Can... · 0 citations

Review Sep 2026

Self-confidence through teaching: Gender differences in medical students’ self-assessment of dermatological skills and learning effects

Background: The ability to assess oneself realistically is central to medical education, as it enables students to identify their own strengths and weaknesses and can help prevent poor decision-making. Previous studies have shown that female students tend to underestimate their competencies, while male students tend to...

I. Heinen, J. Kött, I. Hansen-Abeck et al. · GMS Journal for Medical Educ... · 0 citations