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Author

J. Koff

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2 papers indexed here

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Oct 2026

Abstract C147: U54 Cancer Health Disparities Specialized Program of Research Excellence: The Lymphoma Outcomes SPORE

Diffuse large B-cell lymphoma (DLBCL), the most common hematologic cancer in the US, is characterized by marked molecular and clinical heterogeneity. African American (AA) and Hispanic patients experience inferior outcomes due to biologic factors that remain poorly understood, in addition to well-described socioecono...

J. Koff, Jonathon B. Cohen, Lee A. D. Cooper et al. · 0 citations
Open access Oct 2026

Inhibition of ROR1 signaling with zilovertamab plus ibrutinib in chronic lymphocytic leukemia: safety, mechanistic insights, and an exploratory signal in del(17p) disease.

The receptor tyrosine kinase‑like orphan receptor (ROR1) is aberrantly expressed on chronic lymphocytic leukemia (CLL) cells and promotes survival signaling through NF‑κB, ERK1/2, and mTORC1. Zilovertamab is a humanized monoclonal antibody targeting ROR1. We conducted a multicenter phase 1b/2 study of zilovertamab plus...

M. Choi, E. Ghia, T. Siddiqi et al. · 0 citations

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