J. K. Gupta

CRISPR-Cas9 in Cancer Therapy: Therapeutic Strategies, Delivery Systems, and Immuno-oncology Applications

Cancer genomics has transformed the field of oncology, with cancer now considered a highly heterogeneous and genetically complex disease driven by a variety of somatic and germline alterations. This complexity, which includes mutations in oncogenes and tumor suppressor genes, often undermines conventional therapies...

Medicinal Plants in the Management of Anxiety Disorders: Clinical Evidence, Mechanisms, and Safety Considerations.

Anxiety disorders are among the most prevalent neuropsychiatric conditions worldwide and represent a major public health burden. Although conventional pharmacological treatments are effective, their long-term use is often limited by adverse effects, including sedation, dependence, and cognitive impairment, prompting gr...

Recent Advances in Pharmacological Interventions for Huntington's Disease: Evidence from Clinical Translation.

Huntington's Disease (HD) is a rare autosomal dominant neurodegenerative disorder characterized by progressive motor dysfunction, psychiatric disturbances, and cognitive decline. An expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene causes it to repeat, leading to the production of mutant Huntingtin Protein...

Targeting neurovascular dysfunction in diabetic neuropathic pain: a review of mechanism-based pharmacotherapy beyond gabapentinoids

Exploring the Therapeutic Potential of Bioactive Peptides in Modulating Tau Protein Interactions via the PI3K/Akt Pathway in Neurodegenerative Diseases.

Neurodegenerative Diseases (NDs) represent a growing global health challenge, characterized by progressive neuronal loss and cognitive decline. Central to these disorders are tauopathies, characterized by abnormal aggregation and hyperphosphorylation of tau proteins, leading to synaptic dysfunction and neuronal degener...

Rutin (Quercetin-3-rutinoside): A Comprehensive Review of its Anti-inflammatory and Anti-allergic Mechanisms, Molecular Targets, and Therapeutic Potential.

Rutin exhibits promising anti-inflammatory and anti-allergic activities through multitarget modulation of inflammatory, oxidative stress, and immune pathways, and limitations such as poor bioavailability, variability among experimental studies, and limited clinical validation remain significant challenges.

Integrative Phytotherapy for Neurodegenerative Disorders: Bridging Traditional Botanicals, Bioactive Compounds, and Nanotechnology.

The synthesis of emerging evidence regarding the neuroprotective efficacy of phytotherapy is presented in this review, and the focus is on such traditional medicinal plants as Bacopa monnieri, Withania somnifera, and Centella asiatica.