TLR4 epidermal genetic deletion protects against acute and tumorigenic UV exposure in SKH-1 mouse skin.
Epidermal keratinocytes play a key role in regulating skin immune responses. However, their specific involvement in inflammatory signaling triggered by solar ultraviolet (UV) radiation, which contributes to the development of cutaneous squamous cell carcinoma, is not yet fully understood. It is now known that environme...