Author

J. James

3 papers indexed here

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Open access Sep 2026

Synthesis, In Silico and In Vitro Evaluation of Cholinesterase and Tyrosinase Inhibition of Benzothiazinones for Cognitive Disorders

Objective: Cognitive disorders, including Alzheimer’s disease (AD) are multifactorial conditions associated with cholinergic dysfunction and oxidative stress linked to abnormal melanogenesis. This study aimed to design, synthesise, and evaluate novel benzothiazinone derivatives for their dual inhibitory activity agains...

Sindhu T. J., J. James, Z. C. et al. · International Journal of App... · 0 citations

Sep 2026

Computational Design and Virtual Screening of Enumeration-Generated Benzothiazinone Derivatives as Cholinesterase Inhibitors Using Pharmacophore Modelling, Molecular Dynamics, DFT and ML-Based Predictive Modelling Analysis

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are key cholinergic targets implicated in Alzheimer’s disease (AD), and simultaneous modulation of these enzymes represents a promising strategy for addressing cholinergic dysfunction. In the present study, a comprehensive computational approach was employed...

T. Abhijith, J. James, T. Sindhu et al. · Journal of Computational Bio... · 0 citations

Open access Sep 2026

Investigation of ABL Kinase Inhibitory Potential of Bioactive From Juglans Regia: Molecular Docking, Pharmacophore Modelling and Molecular Dynamics Simulation Study

Objective: The present study aimed to investigate the potential of phytoconstituents of Juglans regia derived from IMPPAT database as inhibitors of the Abelson tyrosine kinase (c-Abl), using in silico tools. Methods: Physicochemical and pharmacokinetic properties were predicted using QikProp, while toxicity profiles we...

Z. Fathima C., J. James, Sindhu T. J. et al. · International Journal of App... · 0 citations