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Open access Oct 2026

PWK genetic background reprograms heterochromatin and malignant epithelial states in Neu-driven mammary tumors

Genetic background can alter the latency and behavior of cancers initiated by the same oncogenic driver, but how inherited variation reshapes the regulatory landscape that permits tumor development remains poorly understood. The PWK genetic background accelerates mammary tumor onset in the NeuT model. We compared PWK N...

Rui Geng, Ryann R. Ray, J. Jacob et al. · 0 citations
Open access Aug 2026

Dissociation of Murine Mammary Gland and Tumor Tissues to Create Highly Viable Single-Cell Suspensions

The dissociation of tissue into single-cell suspensions for analysis aids in understanding what is happening at the cellular level in the tumor microenvironment. A longstanding challenge in obtaining and utilizing primary cells is producing high-quality cell suspensions that preserve cell characteristics for downstream...

Ryann Ray, Wei-Zen Wei, J. Jacob · 0 citations

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