Open access
Aug 2026
Structural origins of species-specific differences in TRPV2 activation
Transient receptor potential vanilloid 2 (TRPV2) is a broadly expressed ion channel implicated in diverse physiological and pathological processes. Despite strong conservation, human TRPV2 (hTRPV2) displays markedly reduced sensitivity to stimuli such as 2-aminoethoxydiphenyl borate (2-APB) and heat compared to rodent...
Tabea C. Fricke, R. Pumroy, Julia A. Rocereta et al.
· Nature Communications · 0 citations