ABSTRACT Recent advancements in single‐cell RNA sequencing (scRNA‐seq) have greatly enhanced our ability to dissect cellular heterogeneity. However, unsupervised clustering often struggles to identify transitional or developmental boundary cells, as existing methods rely on highly variable genes without considering exp...
Fang Huang, Da-Yu Hu, Ya-Qi Dai et al.· Advancement of science· 0 citations
During respiratory virus infection, CD8+ T cells kill infected cells and establish antigen-specific memory, but mechanisms regulating these functions remain incompletely understood. Here, we identify mitochondrial transcription factor A (TFAM)-dependent mitochondrial fitness as a regulator of CD8+ T cell function durin...
Z. Navaeiseddighi, Kai Guo, S. Hasan et al.· bioRxiv· 0 citations
Motivation Pharmacovigilance relies on accurate extraction of structured biomedical entities and their semantic relationships from scientific literature. However, most biomedical information extraction systems address named entity recognition (NER) and relation extraction as separate tasks trained on corpus-specific ar...
An effective 3D co-culture system of breast cancer cells and integrated macrophages for studying dynamic cellular phenotype changes and reciprocal interactions in a heterogeneous environment to mimic aspects of the TME and enhance the accuracy of preclinical in vitro treatment response studies is presented.
Chen Cheng, Brett A. McGregor, J. Hur et al.· PLoS ONE· 0 citations
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