Author

J. Homberg

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Open access Sep 2026

Disrupting peripheral serotonin synthesis drives sex-specific alterations in sociability and cognition, and reshapes the gut-immune-brain axis.

Serotonin (5-HT) regulates neurodevelopment and behavior. Whereas central 5-HT is synthesized by tryptophan hydroxylase (TPH)-2, the TPH1 isoform produces 5-HT peripherally. Although these systems are anatomically segregated, TPH1 gene polymorphisms have been linked to neuropsychiatric vulnerability, suggesting that pe...

Rogério C. R. Castro, N. Alenina, E. E. Natasha et al. · Brain, behavior, and immunit... · 0 citations

Open access Oct 2026

Brain-wide circuit dynamics underlying stress susceptibility and resilience in male mice

Understanding the neurobiological mechanisms of stress susceptibility is key to advancing our insight into stress-related psychopathology like post-traumatic stress disorder (PTSD). Because traumatic events are unpredictable, capturing brain activity during or right after trauma is extremely difficult in humans, crea...

B. Dirven, M. Negwer, Andriana Botan et al. · Translational Psychiatry · 0 citations

Open access Sep 2026

Tph2 deficiency shapes neurodevelopmental behavioral trajectories through interactions with the maternal environment, sex, and the gut microbiome

It is demonstrated that 5-HT depletion disrupts behavioral neurodevelopmental trajectories via interactions between genetic, environmental, and ecological factors, highlighting the importance of accounting for sex, environment, and developmental timing in translational research.

Marta C. F. Samina, Rogério C. R. Castro, Thijs Lodder et al. · Translational Psychiatry · 0 citations