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Author

J. Hayashi

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Open access Sep 2026

Circulating cholesterol fuels SARS-CoV-2 replication via ORF3a.

High levels of "bad" cholesterol increase the risk of cardiovascular disease and are also linked to more severe COVID-19, though the reason has been unclear. We show that low-density lipoprotein (LDL) directly enhances SARS-CoV-2 RNA replication, especially in the Beta variant. The viral accessory protein ORF3a is both...

J. Hayashi, Taha Y. Taha, Irene P. Chen et al. · 0 citations

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