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Open access Oct 2026

Intracellular complement Factor B couples inflammatory sensing to metabolism, chromatin regulation and maladaptive tissue repair

Inflammatory signals are broadly conserved, yet how tissue context converts them into programs of recovery or maladaptive repair remains unclear. Using kidney injury as a model of inflammation-to-repair transitions, we identify an injury-induced proximal-tubule complement program in which cell-intrinsic complement prot...

Tilo Freiwald, Daniel Chauss, Md Tajmul et al. · 0 citations
Open access Aug 2026

Loss of the high-affinity vacuolar Ca2+ pump Pmc1p confers echinocandin tolerance in Candida albicans through enhancing calcineurin-based responses

Signaling through the calcium-activated calcineurin phosphatase promotes fungal survival of stressful conditions including those imposed by antifungal medications. Calcium is an essential secondary messenger that regulates diverse cellular processes in eukaryotes; however, it is also profoundly toxic and cytoplasmic co...

J. Gregor, Ravinder Kumar, C. DeJarnette et al. · 0 citations

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