Antimicrobial resistance (AMR) represents a critical global health challenge in the 21st century, with drug-resistant infections accounting for approximately 4.95 million deaths annually; moreover, forecasts suggest a significant increase in this toll by 2050. Traditional approaches to antibiotic development have demon...
Franklin C. Ezeanowai, A. Ewunkem, L. Kiki et al.· Microorganisms· 0 citations
ABSTRACT Antibiotic resistance is a growing challenge in the treatment of bacterial infections, prompting interest in alternative therapies. Understanding how bacterial populations evolve under different selective pressures is important for predicting resistance pathways. This study aimed to investigate the evolutionar...
Lindsey W. McGee, Noah Radtke, Gretchen S. Taylor et al.· Ecology and Evolution· 0 citations
Background/Objectives: Antimicrobial resistance (AMR) and virulence represent co-evolving dimensions of microbial pathogenic potential whose ecological organization in building-scale wastewater systems remains poorly understood. Methods: Using shotgun metagenomic sequencing, we characterized the temporal dynamics and e...
Ugonna C. Morikwe, Larisa C. Kiki, Franklin C. Ezeanowai et al.· Antibiotics· 0 citations
Examination of evidence surrounding mitochondrial dysfunction, oxidative stress, and gut microbiome dysbiosis across humans, mice, and fruit flies under spaceflight and corresponding terrestrial control conditions finds that biomarker genes most associated with mutation accumulation and antagonistic pleiotropy appear t...
C. Naney, J. Graves, Scott H. Harrison· International Journal of Mol...· 0 citations
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