J. González-Ros

Lipid modulation in a model K+ channel occurs through alterations at both, the inner and the outer channel gates.

This paper reports on a plausible mechanism of modulation by anionic phospholipids of KcsA, a model prokaryotic potassium channel. A first conclusion is that the association of anionic phospholipids with KcsA occurs at discrete regions located near both the extracellular and intracellular channel gates. This same behav...