Synthesis of Poly( α -aminoketones) through Pd-Catalyzed C(sp3)–C(sp3) Cleavage of Azetidinol Monomers
Herein we describe a synthetic route to poly(α-aminoketones) based on the Pd-catalyzed C(sp3)–C(sp3) bond cleavage of N-protected 3-azetidinol monomers containing a haloaryl group. The reactivity of the azetidinols was sensitive to the nature of the N-protecting group. Thus, substrates with N-tert-butyloxycarbonyl or...