The human proteostasis network is operationally defined by providing a comprehensive, annotated, and manually curated list of its components classified into nine Branches based on their function and localization - cytonuclear proteostasis, ER proteostasis, mitochondrial proteostasis, nuclear proteostasis, proteostasis...
Evan T. Powers, Suzanne Elsasser, T. Stoeger et al.· Autophagy· 0 citations
The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Establishing and maintaining proteostasis is the province of the proteostasis network, a highly interconnected system of over 3000 components that regulate protein synthesis, folding, localization, and degradation....
Evan T. Powers, Suzanne Elsasser, Ee Phie Tan et al.· Autophagy· 0 citations
The remarkable and problematic capacity of Mycobacterium tuberculosis to persist in the host is dependent on a functional 20S proteasome that is structurally and functionally analogous to its mammalian counterpart. It has been proposed that this enzyme is critical for the bacterium’s adaptive response to a variety of...
Xilin Gu, Peter J. Rowheder, Zanlin Yu et al.· ACS Chemical Biology· 0 citations
Environmental factors, such as mechanical stress and/or polyanions, play an important role in promoting the thermodynamic stability of otherwise dynamic tau fibrils, and it is speculated that, in patients, such factors might contribute to the maturation of disease-specific conformers.
Wyatt C. Powell, Nicholas L. Yan, Eric Tse et al.· Journal of the American Chem...· 0 citations
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