Author

J. George

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Open access Sep 2026

γδ T cells modulate anti-tumor immunity in small cell lung cancer.

It is demonstrated that γδ T cells are effective at tarlatamab (delta-like ligand 3 [DLL3]-CD3 bispecific T cell engager [BiTE])-redirected SCLC killing and that zoledronate can sensitize SCLC cells to γδ T cell-mediated killing.

Jin Ng, Yue You, Tina Zhang et al. · Cancer Cell · 0 citations

Open access Aug 2026

A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer

This work identified that NMD inhibition boosted neoantigen expression and presentation by tumor cells and increased T cell recognition, thus enhancing overall tumor immunogenicity and further improving immunotherapy efficacy in vivo, uncovering a novel TMB-dependent tractable vulnerability for this devastating disease...

Lucia A. Torres-Fernández, V. Boehm, Joel Kaufmann et al. · Molecular Cancer · 0 citations