Alterations in the oral microbiota are increasingly recognized as an integral component of the tumor microenvironment, forming a clinically relevant oncobiome that may modulate tumorigenesis, therapeutic response, and patient prognosis in head and neck squamous cell carcinoma (HNSCC).
In this prospective s...
R. Granda-Díaz, N. Molinero, Mario Sánchez-Canteli et al.· Microbiome· 0 citations
Terminal differentiation-induced non-coding RNA (TINCR), initially classified as a long non-coding RNA, encodes a biologically active microprotein (pTINCR) involved in epidermal differentiation and tumor biology. However, the clinicopathological and prognostic relevance of pTINCR expression in cutaneous squamous cell c...
Raquel Santos-Juanes, J. Santos-Juanes, Noelia Blanco-Agudín et al.· International Journal of Mol...· 0 citations
Immune checkpoint blockade has revolutionized cancer therapy; however, numerous tumors remain resistant by adopting cellular states that impede immune recognition. In this study, we identify the nerve growth factor receptor (NGFR) as a regulator of immune evasion in head and neck squamous cell carcinoma (HNSCC). Geneti...
J. García-Agulló, V. Santos, B. Majem et al.· bioRxiv· 0 citations
These findings define functionally distinct and pharmacologically targetable CAF programs in HNSCC and support stromal-directed interventions as a rational component of future combination treatment strategies.
Llara Prieto-Fernández, A. Martínez-Carrillo, L. de Villalaín et al.· bioRxiv· 0 citations
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