Conformational stability and domain‐specific structural features of tumor autoantigens regulate autoantibody epitope propensity
Autoantibodies against tumor‐associated autoantigens are clinically valuable biomarkers for cancer diagnosis; however, the structural determinants governing epitope selectivity remain unknown. Here, we investigated whether the intrinsic conformational stability of target autoantigens regulates the epitope propensity of...
Ai Miyamoto, Rika Yamamoto, Ryui Sakaguchi et al.
· Protein Science · 0 citations