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J. Felgner

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Open access Aug 2026

Comparative characterization of novel lipid nanoparticle adjuvants reveals distinct immunogenicity and reactogenicity profiles

Rational design of adjuvants that simultaneously increase immunogenicity and reduce reactogenicity remains a challenge for protein vaccine development. Conventional adjuvants, like aluminum salts, and oil-in-water emulsions (like MF59, AS03, and AddaVax), work well to increase antibody titers but have variable abilit...

J. Felgner, Jenny E. Hernandez-Davies, Andriy V. Yeromin et al. · 0 citations
Open access Jul 2026

Optimizing T Cell Priming Using TLR4/9 Combination Adjuvant For Robust Cell-Mediated Immunity Against Influenza 2307646

Subunit vaccines are safe but rarely induce robust, long-lasting immunity, especially cell-mediated immunity (CMI). Here, we investigated the potential of IVAX-1, a combination of TLR4 (MPLA) and TLR9 (CpG 1018) agonists formulated in a squalene oil-in-water emulsion (AddaVax), to mediate protection and generate...

Dan Nguyen, D. Davies, J. Felgner et al. · 0 citations

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