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Author

J. Essigmann

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Open access Aug 2026

Sex and base excision repair as key susceptibility factors for alkylation-induced mutations, toxicity and hepatic cancer

N-Nitrosodimethylamine (NDMA) is present in food, water, and drugs and is considered a probable human carcinogen by the International Agency for Research on Cancer. The mechanism of action of NDMA involves the generation of carcinogenic methyl lesions such as 3-methyladenine (3MeA) on DNA bases. Alkyladenine DNA Glycos...

Jennifer E. Kay, J. Corrigan, Lindsay B. Volk et al. · 0 citations
Open access Jul 2026

Fluorescent Detection of Aqueous N‑Nitrosodimethylamine via Photochemical Transformation and Affinity Capture

N-Nitrosodimethylamine (NDMA) is a water-soluble carcinogen typically quantified using mass spectrometry coupled with chromatographic separation, which requires extensive sample preparation and sophisticated instrumentation. Here, we report a fluorescence-based detection strategy for NDMA in aqueous media that replaces...

Chi-Hsien Wang, Hsuan-Min Hung, R. G. Croy et al. · 0 citations

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