Author

J. Doloff

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Open access Oct 2026

Polymeric Nanoparticle Gene Delivery to Reprogram the Tumor Immune Microenvironment in Ovarian Cancer for an Anti-Tumor Response.

The tumor immune microenvironment (TIME) in ovarian cancer is highly immunosuppressive, and existing immunotherapies are not effective in 85-90% of patients. To address this, we fabricated nanoparticles (NPs) composed of biodegradable poly(β-amino ester) (PBAE) complexed with plasmids encoding 4-1BB ligand and interleu...

Joanna Yang, Yeongseo Lim, Elizabeth Schmitzer et al. · Acta Biomaterialia · 0 citations

Open access Jul 2026

Formulation and assessment of long-acting pharmaceutical co-formulated crystals.

This work investigates solvent/anti-solvent crystallization as a simple and versatile method for producing single‑drug as well as co‑formulated crystalline depots using curcumin and piperine as a model system and demonstrates that the solvent/anti-solvent ratio strongly modulates crystal properties and accelerated rele...

Jamie L. Hernandez, Neeti R. Prasad, J. Daniel et al. · International journal of pha... · 0 citations

Aug 2026

Engineering Lipid Nanoparticles through Integrated Compositional and Ligand Targeting Enhances β Cell-Directed RNA Delivery.

A dual-targeting LNP engineering strategy that integrates high-throughput compositional screening with surface conjugation of β cell-specific targeting ligands to enable selective gene delivery to pancreatic β cells is developed and establishes a versatile platform for RNA therapeutics and gene-editing applications in...

Di Yu, Yining Zhu, A. Roca-Rivada et al. · ACS Nano · 1 citation