J. D. de Celis

Signaling by RasG12V requires EGFR function in vivo to trigger full downstream pathway activation

Ras proteins regulate signaling pathways initiated by tyrosine kinase receptors, and activating Ras mutations are drivers in cancer and RASophaties. The development of therapies against these diseases requires a profound understanding of how Ras mutations modify pathway output and interact with other pathway compon...