BACKGROUND
Patients with heavily pretreated hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer have few treatment options. Izalontamab brengitecan (iza-bren) is a first-in-class, epidermal growth factor receptor and HER3 bispecific antibody-drug conjugate that cont...
B. Lan, Ye-Hui Shi, Xi-Ying Shao et al.· The Lancet· 0 citations
Importance
Trastuzumab rezetecan (SHR-A1811) has demonstrated encouraging antitumor activity in a global phase 1 trial involving heavily pretreated patients with erythroblastic oncogene B (ERBB2)-low metastatic breast cancer.
Objective
To compare trastuzumab rezetecan vs physician's choice of chemotherapy in patients...
Y. Fan, Yun-Jiang Liu, Yong-Sheng Wang et al.· Journal of the American Medi...· 1 citation
The oral–lung axis describes microbial and inflammatory exchange between the oral cavity and the lower respiratory tract. Its relevance to lung cancer is supported by the detection of oral-associated taxa in lower-airway samples, epidemiological links between periodontal disease and lung cancer risk, and experimental e...
Xiang-Liang Liu, Guan-Ran Ding, Jin Lu et al.· Frontiers in Immunology· 0 citations
MMX and MVX are independently associated with incident AD, supporting the clinical relevance of metabolic health monitoring in neurodegeneration risk stratification.
Guan-Ran Ding, Yu-Ting Liu, Yi-Xin Zhao et al.· Journal of NutriLife· 0 citations
Circulating tumor DNA currently functions mainly as a prognostic and response-associated biomarker in lung cancer immunotherapy, while its predictive, decision-defining role remains an important but investigational objective.
Yan Li, Guan-Yu Lu, Wei Song et al.· Frontiers in Immunology· 0 citations
The need for prospective validation and multidisciplinary collaboration to translate advances in radiomics, AI, liquid biopsy, airway classifiers, and multi-omics integration into clinically useful pathways that improve early lung cancer detection, reduce unnecessary interventions, and enhance patient outcomes is highl...
Yan Li, Guan-Yu Lu, Xiang-Liang Liu et al.· Critical reviews in oncology...· 0 citations
This review examines how tumor-derived signals activate IRE1α/XBP1 to upregulate both the autophagy-lysosome pathway (ALP) and ubiquitin-proteasome system (UPS); its crosstalk with inflammatory and metabolic networks; and the therapeutic potential of IRE1α inhibitors, XBP1-directed strategies, and nutritional approache...
Guan-Ran Ding, Wang Yang, Yi-Xin Zhao et al.· Biochimica et biophysica act...· 0 citations
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